Based on the Kin Gatlin novel "Good Christian Bitches," ABC initially struggled to market the series, which changed its title to "Good Christian Belles" and, ultimately, "GCB" by the time it debuted March 4.
"Our entire ensemble of actors on GCB are saddened," Chenoweth tweeted in response to the May 11 cancellation.
An online petition, savegcb.com, has been launched by fans hoping to convince ABC to bring the series back next season. "GCB" aired its first season finale May 6.
The series also included Annie Potts as Gigi Stopper, Jennifer Aspen as Sharon Peacham, Miriam Shor as Cricket Caruth-Reilly, Marisol Nichols as Heather Cruz, Brad Beyer as Zack Peacham, Mark Deklin as Blake Reilly and David James Elliott as Ripp Cockburn.