The cancellation is due to a "minor but unavoidable surgical procedure," according to a press release from the orchestra.
Hewitt was scheduled to perform Mozart's Piano Concerto No. 23 with the orchestra in Chapel Hill and Raleigh.
In her place, pianist Leon Fleisher will play Mozart's Piano Concerto No. 12. The program also includes Liszt's A Faust Symphony, with tenor Robert Bracey. The orchestra's resident conductor William Henry Curry conducts.
Fleisher is renowned for his mastery of piano works for one hand. In the 1960s, when a neurological ailment prevented him from using his right hand, he played solely with his left. Periodic attempt to return to the standard, two-handed repertoire failed until recent treatments of Botox returned the use of the pianist's right hand.