Kirk joins a cast that includes the previously announced Parker, Elizabeth Perkins and Kevin Nealon. The ten-episode series, produced by Lions Gate Television, will premiere this summer on the cable network. Kirk will play Andy, the younger brother of Nancy Botwin's (played by Parker) dead husband. "Weeds," according to production notes, "exposes the dirty little secrets that lie behind the pristine lawns and shiny closed doors of homes in the fictional town of Agrestic, California. Parker stars as a suburban mom who resorts to selling marijuana in order to support her family after her husband unexpectedly dies. Perkins stars as the uptight and dysfunctional head of the PTA and Nealon plays a pot-smoking city councilman."

"Weeds" is executive produced by Jenji Kohan. Brian Dannelly directed the series premiere.

Justin Kirk received an Emmy Award nomination for his performance as Prior Walter in the TV miniseries "Angels in America." He received an Obie Award for his work in Love! Valour! Compassion and a Lucille Lortel Award for his performance in Ten Unknowns. Kirk's other theatrical credits include Any Given Day, Evolution, June Moon, Tatjana in Color, Old Wicked Songs and Spine.