The world-premiere production, directed by Robert Falls, will open Feb. 8, 2012, in Los Angeles.

In The Jacksonian by Pulitzer Prize winner Henley (Crimes of the Heart), Harris, a four-time Oscar nominee and Broadway veteran who recently appeared at the Geffen Playhouse in Wrecks, "plays Bill Perch, a dentist with ambiguous morality who goes to The Jacksonian to bury his secrets," according to Geffen notes. "Estranged from his wife, played by Oscar nominee Amy Madigan (Broadway's Streetcar Named Desire), Perch makes his new home in the motel's unsettling world where the subversive becomes commonplace and the passage of time becomes hauntingly unpredictable. As the Perchs' lives become intertwined with the inhabitants of the motel — proprietor Fred Weber played by Bill Pullman (most recently seen on Broadway in Oleanna) and bartender Glenne Headly (of the film 'Dirty Rotten Scoundrels') — the audience is taken on a surreal trip that is rife with disturbingly dark humor."

Director Falls is artistic director of The Goodman Theatre in Chicago. The Jacksonian will begin previews Jan. 31, 2012, in the Audrey Skirball Kenis Theater at the Geffen Playhouse. Performances are scheduled to play through March 11.

"I am humbled and awestruck to be working with the artists who are involved in this premiere production," playwright Henley said in a statement. "It is an honor and a joy — a sublime situation. I plan to relish every moment."

Harris, Headly, Madigan and Pullman were all involved with Henley in early readings of the play. There is one remaining actor to be announced for the role of Rosy Perch, the daughter of Susan and Bill Perch.

Tickets for The Jacksonian are currently available through subscription only. Visit www.geffenplayhouse.com.