Directed and choreographed by Christopher Gattelli, the production will play a limited engagement through Aug. 13.

The cast will be headed by Brent Barrett and Jenn Harris with Stephen Bienskie, Harry Bouvy, Deidre Goodwin, Jeff Hiller, Howard Kaye and Alysha Umphress.

Silence! The Musical features a book by Hunter Bell and music and lyrics by Jon and Al Kaplan.

In the Academy Award-winning film "The Silence of the Lambs," press notes state, "rookie FBI agent Clarice Starling matches wits with the brilliant but insane cannibal, Dr. Hannibal Lecter, to catch the serial killer known only as Buffalo Bill. Clarice must face her own demons and race the clock to unlock Lecter’s clues before another innocent girl is killed and skinned by Bill. It’s a hair-raising thriller that’s kept countless millions on the edges of their seats and permeated the pop lexicon with delightfully creepy quotes like 'I ate his liver with some fava beans and a nice Chianti' and of course 'It places the lotion in the basket.' And now, at last, this delicate symphony of suspense has been turned on its ear and retold in the only way it can be – as a musical. A singing chorus of floppy eared lambs narrates the action; Buffalo Bill gleefully dances a hoedown while kidnapping hapless Catherine Martin; and even Dr. Lecter, scary as ever, sings about the life he’d like to lead someday outside the prison walls."

The production will also feature musical direction by Mark Hartman with arrangements and orchestrations by Brian J. Nash. Silence! is being produced Off-Broadway by Victoria Lang, Rich Affannato and Donna Trinkoff.

Silence! was the winner of the 2005 FringeNYC award for Outstanding Musical.

Show times will be Fridays at 8 PM and Saturdays at 8 PM and 10:30 PM.

Theatre 80 is located at 80 St. Marks Place (between First & Second Ave.). Tickets are $38 and are available by calling (212) 352-3101 or through www.SilenceTheMusical.com.