Among the cast are Broadway actors Latrisa Harper (The Color Purple), Aisha Jackson (Beautiful: The Carole King Musical), Corey Mach (Hands on a Hardbody) and Jamard Richardson (The Book of Mormon).

Invisible Thread, which blends African beats and a world pop score, will begin previews Oct. 31 with an official opening night scheduled for Dec. 2.

The cast also features co-creator Griffin Matthews with Nicolette Robinson (Brooklynite), Tiffany Mann (Sweeney Todd at Lincoln Center), Conor Ryan (John & Jen), Melody Betts ("Chicago PD"), Rodrick Covington (Central Avenue Breakdown), Kevin Curtis (A Chorus Line national tour), Tyrone Davis, Jr. (Shrek national tour), Nkrumah Gatling (Hair), Jason Herbert (Fela! tour), Kristolyn Lloyd (Heathers The Musical), Michael Lluwoye (Fable), Jeremy Pope (Choir Boy), Adeola Role (Lily’s Revenge) and Jamar Williams (Broken Window Theory).

Matt Gould and Matthews' Invisible Thread, previously titled Witness Uganda, had its world premiere at American Repertory Theatre in 2014, helmed by Tony winner Paulus and featuring many of the newly announced Off-Broadway cast. Based on the real-life experiences of co-creator Matthews, the musical follows the life-changing journey of a young New Yorker who volunteers for an aid project in Uganda. "When his altruistic aspirations collide with the real world," describe press notes, "his life is changed in unexpected and profound ways."

As Playbill reported last month, the show was able to crowd-fund enough money to send the the cast, creators and a film crew to Uganda. In preparation for the New York premiere staging, the troupe would meet the real-life Ugandan students on which the show is based, as well as take part in the mentoring of orphans and helping a local AIDS clinic, among other volunteer projects. Paulus has been attached to the project's development for several years and oversaw staged readings in New York late last year. Over the last few years, the musical, which is the winner of the 2012 and 2014 Richard Rodgers Award, has raised over $200,000 for the students' educations in Uganda.

Single tickets will go on sale Sept. 16. For more information visit 2ST. Second Stage Theatre’s Tony Kiser Theatre is located at 305 West 43rd St.