Irishman O'Byrne won the Best Featured Actor Tony for Frozen and was nominated for Doubt, the Broadway production of which he exits Jan. 8.
In Shining City he will play a therapist treating a man (played by Oliver Platt) who says he's been visited by the ghost of his dead wife.
Tony Award winner Robert Falls (Long Day's Journey Into Night, Death of a Salesman) directs.
"[We] are thrilled that Brían will be returning to Manhattan Theatre Club to star in this wonderful play along with Oliver Platt," MTC artistic director Lynne Meadow said in a statement. "Brían is one of the most talented actors working in theatre today and we are so proud that his next role after his stunning performance in Doubt will be in another MTC production."
Previews for Shining City begin on April 13 for a May 3 opening. *
Shining City was originally produced at London's Royal Court Theater to critical acclaim. The play is set in Dublin, "where a guilt-ridden man (Platt) reaches out to a therapist (O'Byrne) after seeing the ghost of his recently deceased wife," according to MTC. "Wrestling with his own demons, the therapist can only do so much to help. Routine visits between the two men quickly become a gripping struggle to survive, changing both of them for the rest of their lives."
Additional casting will be announced at a future date.
McPherson is best known for London and Broadway play, The Weir, but also penned Dublin Carol, This Lime Tree Bower and St. Nicholas.
Single tickets are available by calling TeleCharge.com at (212) 239-6200 or at www.telecharge.com or at the Biltmore Theatre box office (261 West 47th Street).