Directed by John Dapolito, the production will officially open Dec. 3 and continue through Jan. 6, 2013.
The cast will feature Adam Mucci, Katie Webber, Brandi Nicole Wilson and James Wirt.
"A family, a will, a gun, a marriage, an affair, a wheelchair and a murder attempt… just your normal Christmas holiday!," press notes state. "Let’s Kill Grandma This Christmas is a rip-roaring holiday black comedy that takes place as a family gathers to celebrate Christmas Eve dinner. After a rough year rife with economic difficulties, some family members ponder the question...at 80 years old, how much longer does Grandma need to hold on to her vast fortune?"
Sets and lights will be designed by Harry Feiner. Casting is by Judy Bowman.
Theatre at St. Clement’s is located at 423 West 46th Street. Tickets are $69 and can be purchased by clicking here.