Among other names joining Chenoweth and Tucci for the movie are Andy Samberg, Jeff Daniels, Kenan Thompson and Patrick Warburton. According to The Hollywood Reporter, "Saturday Night Live" cast member Andy Samberg will play Ham III, the grandson of the first chimp space astronaut, who is lured by a Senator, played by Tucci, to travel through space in order to help an alien planet overthrow their evil leader. Chenoweth will voice one of the aliens.
"Space Chimps" has music by the Eurythmics' Dave Stewart with additional material and sound design provided by Blue Man Group.
Scheduled for release next year, "Space Chimps" is produced by Vanguard Animation and Starz Media production for 20th Century Fox.