Directed by Katherine Kovner, the cast will also feature Kieran Campion (Pygmalion, Journey's End), Brandon Espinoza (Scarcity at Atlantic Theater) and Shana Dowdeswell (The Diary of Anne Frank at Paper Mill Playhouse). Opening night is set for May 4; the production will run through May 17.

In Substitution, press notes state, "Calvin's Mom is coping with the death of her teenage son as best as she can. When a substitute teacher challenges everything she thinks she knows about Calvin, their volatile bond creates a complex unfolding of revelations. Ultimately, she discovers that the choices we make about how we live and how we love can bring about endless surprises."

The production will feature set design by Tom Gleeson, costume design by Theresa Squire, lighting design by Jeff Croiter and sound design by Jill BC DuBoff.

Jan Maxwell has been seen on Broadway in City of Angels, Dancing at Lughnasa, A Doll's House, The Sound of Music, The Dinner Party, Match, Sixteen Wounded, Chitty Chitty Bang Bang and Coram Boy. She received Tony nominations for her work in the latter two productions. Maxwell is also a Drama Desk Award winner for her performance as Baroness Bomburst in Chitty. The actress recently took part in a workshop of the Broadway-bound musical Cry-Baby.

Substitution was penned specifically for Maxwell. Show times are Tuesday-Friday at 7:30 PM, Saturday at 3 and 7:30 PM and Sunday at 3 PM.

SoHo Playhouse is located at 15 Vandam Street between Sixth Ave & Varick Street. Tickets, priced $30, are available by calling (212) 691-1555 or by visiting www.sohoplayhouse.com.

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The Playwrights Realm is a new Off-Broadway theatre company dedicated to "developing and producing theater with artists who share our belief that the playwright's vision is central to great theater." John Dias and Katherine Kovner are co-artistic directors.