Known for her roles on "NYPD Blue," "Judging Amy" and "Private Practice," Brenneman co-created the piece with Sabrina Peck. It will play a limited run through May 29 on the Loeb Stage.

Mouth Wide Open, according to A.R.T. "juxtaposes a hunger for the spiritual with the externalized pressures of celebrity. From a Tibetan temple in Kathmandu to an evangelical church in the Mississippi Delta, from the hype of the red carpet to the cold reality of a hospital room, Brenneman is our guide on an epic journey that takes us to the place where illness and spirituality collide. This fearless look at the ecstatic, irreverent, and sometimes excruciating dance between the sacred and the profane harnesses the intimacy of a confessional and the heightened theatricality of the stage as Brenneman tells her story with dazzling candor."

Brenneman previously appeared at A.R.T. in Measure for Measure. Her stage credits include The Learned Ladies for Classic Stage Company, Saint Joan of the Stockyards at Yale Rep, A Nervous Smile at Williamstown Theatre Festival and God's Heart at Lincoln Center Theater.

For tickets visit AmericanRepertoryTheater. A.R.T. is located at 64 Brattle Street in Cambridge, MA.