The fifth annual event will be presented by co-founders Robert De Niro, Jane Rosenthal and Craig Hatkoff in the namesake downtown New York City locale, April 25-May 7.

Charles Busch (Taboo) directs and co-writes (with Carl Andress) the film "A Very Serious Person" to make its world premiere at the festival. In the film, "A traveling male nurse from Denmark takes a new job with a terminally ill Manhattan woman raising her parentless thirteen-year-old grandson and the emotionally reserved man finds himself oddly cast as a mentor to the boy." Stage stalwarts Polly Bergen, Dana Ivey and Julie Halston also appear.

Hedwig and the Angry Inch fans will recognize the tunes central to the documentary feature "Follow My Voice: With the Music of Hedwig." Katherine Linton directs the world premiere which features Jonathan Richman, Sleater-Kinney, Rufus Wainwright and other musicians as they record a benefit album of the musical's songs for the Hetrick-Martin Institute. The film follows four students at the home of the Harvey Milk High School, the first LGBTQ high school in the country.

Stage performers can also been seen in a number of the films including Anthony LaPaglia (A View from the Bridge, The Guys) and Isabella Rossellini (The Stendhal Syndrome) in "The Architect" based on Scottish playwright David Greig's work of the same name. Evita's Mandy Patinkin appears in Steve Barron's "Choking Man," Steppenwolf Theatre Company ensemble member John Malkovich can be seen in the French entry "Colour Me Kubrick" as "a conman who successfully passed himself off as the famed and notoriously reclusive director for the last decade or so of the filmmaker's life."

Fellow Steppenwolf actress Martha Plimpton (Hedda Gabler) co-stars with recent A Streetcar Named Desire Tony Award nominee Amy Ryan and upcoming Everything's Turning Into Beautiful star Annabella Sciorra in "Marvelous." Robert Edwards' "Land of the Blind," a satirical political drama stars Faith Healer star Ralph Fiennes opposite Donald Sutherland (Ten Unknowns, Lolita). Sigourney Weaver (The Mercy Seat, Mrs. Farnsworth) will star in "The TV Set" by Jake Kasdan.

Among other stage actors to be seen are Judd Hirsch in "Brother’s Shadow, Christine Baranski in "East Broadway" and Kristen Bell in "Fifty Pills." Mark Webber (The Distance From Here) and Rosie Perez (Frankie and Johnny in the Clair de Lune) "Just Like the Son."

For more information on the upcoming Tribeca Film Festival, visit the website at www.tribecafilmfestival.org.