Producers of the Broadway hit, Proof are talking to Anne Heche about taking over the role of Catherine, the troubled daughter of a math genius who may or may not have inherited his mental illness.

Mary-Louise Parker (Prelude to a Kiss, "Fried Green Tomatoes") created the central role in the David Auburn play when it began Off-Broadway at Manhattan Theatre Club. She won the Best Actress Tony when it moved to the Walter Kerr Theatre in 2000-2001, and Auburn picked up the Best Play Tony Award and the 2001 Pulitzer Prize for Drama. Jennifer Jason Leigh ("The Anniversary Party," Cabaret on Broadway) took over the role of Catherine in September 2001 and leaves the show June 30, along with other cast members.

A spokesman confirmed that Heche was in discussions to take on the angst-ridden character in the play. Heche's most high profile role may have been in the Harrison Ford picture, "Six Days Seven Nights," and she became widely known for having been Ellen DeGeneres' partner and for a very public breakdown, which she chronicled in her memoir, "Call Me Crazy."

An official announcement of the new cast is expected in the coming weeks. The current cast also includes Seana Kofoed, Patrick Tovatt and Josh Hamilton.

The national tour, led by Chelsea Altman and Robert Foxworth, with Stephen Kunken and Tasha Lawrence, winds down in late June. Daniel Sullivan won the 2001 Tony Award for Best Director (Play) for Proof.