Skeggs assumes the role of Medium Alison and Kuhn takes back the role of family matriarch Helen Bechdel. Both actresses were nominated for Tony Awards for their performances in those roles.
Kuhn took a leave of absence from the show April 5–May 22 to undergo hip surgery. She was replaced during that time by Rebecca Luker, herself a Tony Award nominee for Mary Poppins, The Music Man and Show Boat.
The cast also features Tony Award winner Michael Cerveris, Tony Award nominee Beth Malone, Lauren Patten, Gabriella Pizzolo, Roberta Colindrez, Cole Grey, Zell Steele Morrow, Joel Perez, along with Alessandra Baldacchino, Kally Duling, Maya Grace Fischbein, Perry Sherman, Jim Stanek and Nicole Van Giesen.