Daniel Craig, the current James Bond, is in talks to co-star. The film is adapted by Don McKellar from Nobel Prize winner Jose Saramago's novel about an epidemic of blindness that sweeps through an unnamed contemporary city. Moore, whose other upcoming film credits include "Next" and "Savage Grace," just ended her run in David Hare's Vertical Hour March 11.

Moore has earned four Academy Award nominations for her work in "The Hours" (a Hare screenplay), "Boogie Nights," "Far From Heaven" and "The End of the Affair." Other film work includes "The Shipping News," "Evolution," "Hannibal," "An Ideal Husband," "Magnolia," "The Big Lebowski" and "Children of Men." Her stage credits include Vanya on 42nd Street Off-Broadway as well as Surviving Picasso, Serious Money and Ice Cream With Hot Fudge.

The production companies on "Blindness" include Potboiler Productions, Rhombus Media, Bee Vine Pictures and Meirelles' company 02 Filmes. Focus is handling foreign sales, but there is not yet a U.S. distributor. Niv Fichman, Simon Channing-Williams and Gail Egan are producing.