The season premiere is scheduled for Sept. 10; check local listings for air times.
Season co-hosts will also include Goldie Hawn, Kelly Osbourne, Cyndi Lauper, Howie Mandel, Erin Andrews, D.L. Hughley and Kellie Pickler.
Chenoweth co-hosted twice with Cooper during the chat show's first season and famously surprised a young fan on stage.
Visit AndersonCooper.com for more information. Chenoweth won the Tony Award in 1999 for her performance in You're A Good Man, Charlie Brown. She was nominated in 2004 for her performance in Wicked and has also been seen on Broadway in Steel Pier, Epic Proportions, The Apple Tree and Promises, Promises. The actress is also known for her film and television work, including the recent ABC series "GCB."
Her new CD, "Some Lessons Learned," arrived Sept. 13, 2011, on the Sony Masterworks label.