Goldblum will play Scott Woolley and LuPone will play her celebrity self in an episode titled "Don't Lie to Me Argentina." "Will & Grace" airs on NBC-TV 8:30-9 PM ET; check local listings.

The upcoming episode, according to the comedy's official website, is described thusly: "Scott Woolley (guest star Jeff Goldblum), Karen's nemesis, hires Grace (Debra Messing) to design his new restaurant under the condition that Grace fires Karen (Megan Mullally) from her design firm. Grace later tells Karen about the incident and they realize the man that hired Grace is really Scott Woolley. Grace and Karen decide to trap him in his lie. Meanwhile, Jack (Sean Hayes) takes Will (Eric McCormack) out for a boys' night to get his mind off of Vince, but ends up abandoning Will at the club. Will upset over being dumped at the club confronts Jack about his behavior. The nest day, Will confronts Jack about his selfish behavior and, in an effort to make amends, Jack takes Will out to dinner and tries to focus all of his attention on his friend. That grows difficult when Broadway star Patti LuPone (Evita) enters the restaurant."

A Tony Award winner for her work in Evita, Patti LuPone also earned an Olivier Award for her performances in the West End productions of Lés Misérables and The Cradle Will Rock. Her other theatrical credits include Sunset Boulevard, Anything Goes, Oliver!, Working, The Old Neighborhood, Master Class and Pal Joey. LuPone also headlined two solo Broadway concerts, Patti LuPone On Broadway and Matters of the Heart, and received glowing notices for her performance as Mrs. Lovett in the Lincoln Center concert version of Stephen Sondheim's Sweeney Todd. For the past four summers she has appeared in concert versions of Sondheim's Sweeney Todd, Passion, A Little Night Music and Sunday in the Park with George at the Ravinia Festival in Chicago, IL.

Jeff Goldblum has appeared on Broadway in Two Gentlemen of Verona, The Moony Shapiro Songbook, The Play What I Wrote and will soon be seen in The Pillowman. He was nominated for an Academy Award for his work in "Little Surprises," and his numerous screen credits also include "The Fly," " The Lost World: Jurassic Park," " The Life Aquatic with Steve Zissou," "Igby Goes Down," "Cats & Dogs," "One of the Hollywood Ten," "Chain of Fools," "Mad Dog Time," "Independence Day," "Powder," "Nine Months," "Hideaway," "Jurassic Park," "Deep Cover," "Framed" and "Mister Frost."