The show will run until Oct. 17. Paul Ford will be at the piano.
The five-stage complex's fall tenants include Basil Twist's underwater puppet spectacle Symphonie Fantastique (already playing) and Daniel Goldfarb's Modern Orthodox and the musicals The Immigrant and Bare.
Patinkin remains best known for the two shows that established his reputation as a musical company star: Evita and Sunday in the Park With George. In recent years, he has concentrated on solo concerts, including Celebrating Sondheim, Mamaloshen and Mandy Patinkin in Concert, which has all played Broadway.
American pop songs and show tune fans have flocked to Patinkin's intimate concerts over the years.
Dodger Stages is located at 340 West 50th Street, between Eighth and Ninth Avenues. The 61,300-square-feet of space, owned by Equity Office, contains five performance venues in a former underground movie multiplex and will be completed at a cost of $20 million.