The Two and a Half Men star will be Vice Principal Douglas Panch in the revival.
Alan Kliffer will direct Dylan MarcAurele's parody of the streaming series Off-Broadway.
Matthew Gardiner will direct the Stephen Schwartz-Roger O. Hirson musical.
Michael Herwitz will direct the musical penned by Ben Diskant.
Playbill's resident Phantom "super Phan" documents her experience utilizing the show's "ADA track," a program tailored to accommodate a number of disabilities.
The award showcase takes place May 16.
Audience members will be given wireless headphones upon arrival and be able to move freely alongside performers.
Tony winner Francis Jue will host the evening benefiting Broadway Cares.
The Tony-winning Jerry Herman-Harvey Fierstein musical will star Billy Porter and Wayne Brady.