Ireland will play Natasha and Rylance will play the role of Irina.
The two actresses join the previously announced 2010 Academy Award nominee Maggie Gyllenhaal (Masha), Josh Hamilton (Andrey), 2010 Tony Award nominee Jessica Hecht (Olga) and film and stage actor Peter Sarsgaard (Vershinin). Also featured in the cast are Ebon Moss-Bachrach (Tuezenbach), Glenn Fitzgerald (Solyony), Roberta Maxwell (Anfisa), Louis Zorich (Chebutykin), George Morfogen (Ferapont), Paul Lazar (Kulygin), Gabe Bettio (Rohde) and James Patrick Nelson (Fedotik).
The production, which features a translation by Paul Schmidt, will officially open Feb. 3, 2011, at 7 PM and continue through Feb. 20.
The creative team for Three Sisters will include set designer Walt Spangler, costume designer Marco Piemontese, lighting designer Keith Parham and hair designer Paul Huntley, with sound design and original music by Christian Frederickson and Ryan Rumery.
Three Sisters will perform Tuesdays through Fridays at 8 PM; Saturdays at 2 PM and 8 PM and Sundays at 2 PM.
Tickets are $75 for weekday performances and $80 for weekends. For tickets and information, visit www.classicstage.org or call (866) 811-4111, or (212) 352-3101, or visit the CSC box office at 136 East 13th Street.