Shepard’s 1980 play, directed by Lindsay Posner, will officially open at the Apollo Theatre, Shaftesbury Avenue, June 13; previews begin June 7.

Lewis will be making her professional stage debut in the production. She became internationally known with her appearance in Scorsese’s 1991 remake of “Cape Fear” for which the then 17-year-old Lewis received Oscar and Golden Globe nominations. Leading roles followed in such films as “Kalifornia” with Brad Pitt, “What’s Eating Gilbert Grape?” with Johnny Depp and “Natural Born Killers,” in which she played the homicidal Mallory opposite Woody Harrelson.

New Zealand-born Henderson has carved a career in Hollywood appearing with Nicolas Cage and Christian Slater in “Windtalkers,” followed by the 2003 horror remake “The Ring.”

The cast also includes Larry Lamb (The Price) and Joe Duttine (My Night With Reg).

In recent years Posner has become one of London’s foremost directors of American drama with a series of high-profile productions of David Mamet plays, including Oleanna, starring Aaron Eckhart and Julia Stiles; A Life in the Theatre with Patrick Stewart and Joshua Jackson; Sexual Perversity in Chicago with Matthew Perry, Minnie Driver and Hank Azaria; and, most recently, Mamet’s farce Romance with “Frasier” star John Mahoney. Fool for Love is set in a motel room near the Mojave Desert and focuses on the tempestuous relationship between stuntman Eddie (Henderson) and May (Lewis). The relationship was formed before they knew of their disturbing common past.

The play received its premiere in New York in 1983 with a cast including Ed Harris, Bruce Willis and Kim Basinger. Basinger also starred with the author in the Robert Altman movie version in 1985.

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