Directed by Frank Ventura, the company's executive artistic director and co-founder, the limited engagement will continue through March 24.
Marrying George Clooney will feature a cast that includes Meghan Duffy (Grease), Eliza Ventura (CAP21 artistic director and co-founder) and Emmy nominee Colleen Zenk ("As the World Turns").
Marrying George Clooney: Confessions From a Midlife Crisis, according to CAP21, "is a sharp-witted new play about three menopausal women wide-awake at 3 AM trading prescription drugs online, revealing their passions, and Googling old boyfriends, while stressing over the mother of all issues: moms."
Other members of the creative team include set designer Jon Knust, lighting designer Clark Gaesser, media designer Grant McDonald, costume designer Julia Broer and sound designer John Emmett O'Brien.
Founded in 1993, CAP21 Theatre Company produces new musicals and new plays by emerging and established theatre writers.
The CAP21 Black Box Theater is located at 18 West 18th Street. For more information and tickets, visit www.cap21.org.