Weisz would portray Emma, who is having an affair with her husband's best friend. Craig would portray Robert, her husband. Potential casting for the role of the friend, Jerry, was not reported.
Nichols recently staged the celebrated Broadway revival of Death of a Salesman.
Craig ("Skyfall," "GoldenEye," "Casino Royale," "The Girl with the Dragon Tattoo") last appeared on Broadway in A Steady Rain. Betrayal would mark Weisz's Broadway debut. Her films include "Oz the Great and Powerful," "The Bourne Legacy," "The Constant Gardener" and "The Shape of Things."
Pinter's 1978 drama travels in reverse dramatic order as it explores a hidden love affair. It premiered on Broadway in 1979 with Blythe Danner, Raul Julia and Roy Scheider. A 2000 revival featured Juliette Binoche, Liev Schreiber and John Slattery.