The hour-long series, to be produced by the U.K.-based ITV, will not air on Saturday nights. A title for the show has yet to be announced.
It is expected that the series will tape in New York. Ten episodes have been ordered.
"As I watched the show, I couldn't stop smiling. Now that I've seen many seasons, my face hurts. It's a game changer," Harris told New York Magazine. "Nothing like this has been done before, and it's unique structure fits right into my random skill set. I can't wait to roll up my sleeves and have some fun!"
Harris, who has emceed the Tony Awards four times and the Emmys twice, will make his Oscars hosting debut in 2015. He has been honored with four Emmy Awards: three for his acclaimed hosting of the Tony Awards and another for his guest-starring role on "Glee."
He won the 2014 Best Actor in a Musical Tony Award for his performance in Hedwig and the Angry Inch. He has performed on Broadway in Assassins, as well as Cabaret and Proof, and in the New York Philharmonic production of Company.
His memoir, "Neil Patrick Harris: Choose Your Own Autobiography," was released Oct. 14.