O'Donnell will appear in the season's second episode on Oct. 2. That episode is titled "The Bowtie." Avid Broadway supporter O'Donnell made her Broadway debut as Rizzo in the 1994 revival of Grease!. The actress and one-time talk-show host later did a stint in the musical Seussical. O'Donnell will begin performances Sept. 20 as Golde to Harvey Fierstein's Teyve in the current Fiddler revival. She has also produced the Broadway run of Boy George's Taboo.

The half-hour situational comedy "Curb Your Enthusiasm," which airs on the HBO cable network Sundays at 10 PM (ET), starts another 10-episode season centering around the neurotic writer Larry David, who stars as himself in a fictional depiction of his real life. Actors Cheryl Hines and Jeff Garlin co-star as David’s wife Cheryl and David’s manager Jeff opposite a cast of real-life celebrities who play themselves. The comedy is based on storylines by David.

Last season featured a slew of stage performers appearing on the show as one storyline saw David becoming the new Max Bialystock in The Producers on Broadway. Among previous guest stars are Nathan Lane, Mel Brooks, Cady Huffman, Ben Stiller, David Schwimmer and the late Anne Bancroft.

O'Donnell joins the lineup of new guest stars, which will also include Kevin Nealon, Mekhi Phifer, Frank Whaley and returning guests Ted Danson, Susie Essman, Richard Lewis and Wanda Sykes.

"Curb Your Enthusiasm" first aired on HBO in 2000. The show is executive produced by Larry David, Jeff Garlin and Gavin Polone. Executive producers/directors are Robert B. Weide and Larry Charles. Tim Gibbons produces with co-producer Erin O'Malley.

For more information on "Curb Your Enthusiasm," visit HBO's website at www.hbo.com.