LAB co-artistic director Philip Seymour Hoffman will direct Little Flower, which is scheduled to begin previews March 18 and open April 6 at the Public Theater (who co-produce the event) for a run through April 20.

The new work from Guirgis centers on the tale of an ailing woman who unknowingly ends up at an upper Manhattan charity hospital while her son struggles to deal with her condition. Casting has yet to be announced.

Little Flower, seen at the 2005 and 2006 Barn Series Festival and developed at Manhattan Theatre Club's "6 @ 7" series, reteams the playwright and director of The Last Days of Judas Iscariot, In Arabia We'd All Be Kings, Jesus Hopped The 'A' Train and Our Lady of 121st Street. Previous readings featured Hoffman in a cast that also included Anne Meara and Eric Bogosian as well as Jeffrey DeMunn, Stephen McKinley Henderson and David Zayas.

Next up for the company will be Brett C. Leonard's UNCONDITIONAL (starting Feb. 7) as directed by Mark Wing Davey. The Off-Broadway troupe's season will also present developmental runs of Rebecca Cohen's Penalties & Interest (June 10-28), directed by John Gould Rubin; and Scott Hudson's Sweet Storm (June 29-30), directed by Padraic Lillis.

Tickets to The Little Flower of East Orange, at the Public Theater's Martinson Hall, 425 Lafayette Street, will available in February by calling (212) 967-7555 or online at labtheater.org.