Shakespeare's tragedy, the final offering in the Donmar's current season, officially opens Dec. 4. Ejiofor was last seen on the Donmar stage in 2002 in The Vortex, Grandage's inaugural production as Donmar artistic director. McGregor played Sky in Grandage's West End revival of Guys and Dolls. On screen McGregor's extensive credits include "Moulin Rouge," "Star Wars" and "Trainspotting."

Ejiofor's other stage credits include Ian Rickson's New York-bound Royal Court production of The Seagull starring Kristin Scott Thomas. Film credits include "Dirty Pretty Things" and "American Gangster."

Joining Ejiofor and McGregor in Othello is Kelly Reilly (After Miss Julie at the Donmar, Piano/Forte), who takes on the role of Desdemona. The cast also features Edward Bennett (Measure for Measure for Peter Hall's Bath season), Michelle Fairley (The Wild Duck), Michael Hadley (The Vortex), Tom Hiddleston, Michael Jenn, Martina Laird, James Laurenson, David Mara and Alistair Sims.

For more on Othello, which is booking until Feb. 23, 2008, call (0)870 160 2878.