The film follows four men attempting to rescue a group of captives from a band of cannibals.
Wilson, who will play the cowboy Arthur O'Dwyer, who is rising to the position of a foreman before his plans are interrupted by an unfortunate accident.
Wilson will co-star with Matthew Fox ("Lost," "World War Z"), along with Kurt Russell ("Vanilla Sky," "The Thing") and Richard Jenkins ("Olive Kitteridge," "The Cabin in the Woods").
The film is written by S. Craig Zahler, who will also direct.
Wilson is a two-time Tony nominee for Oklahoma! and The Full Monty. He has also appeared on Broadway in Barefoot in the Park and All My Sons. His screen credits include "Angels in America," "Little Children," "The Watchmen" and "The Phantom of the Opera." He recently appeared in a concert performance of Guys and Dolls at Carnegie Hall, alongside Nathan Lane and Megan Mullally. Watch Wilson in performance here.