The production, mounted by Peccadillo artistic director Dan Wackerman at the East 13th Street Theatre (136 East 13th Street), will run Sept. 7-Oct. 23. It previously played the Bank Street Theatre in spring 2003.

Ladies takes place in New York City's Hotel Marlow, which is populated by "women of a certain age" who haven't fared terribly well in matters familial and romantic. Among the residents: Lulu Ames, a widow carrying on with a much younger man; Mildred Tynan, who flees an abusive husband only to partner with an alcoholic; and Grace Nichols, who intends to keep her son close at all costs.

Parker wrote few plays. Ladies is sprinkled with Parker's characteristically corrosive wit and mordant view of life. Though the original 1953 Broadway production had a short life (45 performances), Parker was reportedly as proud of the work as she was of anything she had ever written. The original cast included such Broadway veterans as Vera Allen, Edna Best, Betty Field and Frances Starr. (It was the last Broadway play for Allen and Starr.) Also in the cast were Lonny Chapman and Walter Matthau. Harold Clurman directed.

d'Usseau's other major credits are Deep in the Roots and Tomorrow the World, both of which had healthy runs on Broadway in the 1940s. Parker and d'Usseau collaborated on one more play, The Ice Age, but it was never produced.

The Peccadillo cast includes most of the same performers from the 2003 production, including Kelly AuCoin, Ron Badgen, Hal Blankenship, Patrick Boyd, Peggy Cowles, Jo Ann Cunningham, Dawn Evans, Libby George, Susan Jeffries, Andy Phelan, Carolyn Seiff and Susan Varon. New to the cast is Domenica Cameron-Scorsese, daughter of author Julia Cameron and acclaimed film director Martin Scorsese. Tickets are $55. Call (212) 279-4200 or visit www.ticketcentral.org.