De Shields' "commitment to a role in a film with a shooting schedule that conflicts with performances of Prophecy precipitated his need to leave the production," according to a press statement.
The cast also boasts the previously announced Kathleen Chalfant (Obie Award and Drama Desk Award for Wit) and Obie Award winner George Bartenieff as well as Najla Said, who will repeat the three roles she played in the London production, and Brendan Donaldson. Playwright Karen Malpede will direct.
Opening night is scheduled for June 8, and performances will continue through June 20.
Peter Francis James earned Obie, Lortel and Drama Desk Awards for his performance in Stuff Happens at the Public Theater. He starred opposite Dame Maggie Smith in Albee's The Lady from Dubuque in London, and on Broadway in On Golden Pond, Judgment at Nuremberg and Drowning Crow.
Prophecy, according to press notes, "is both the story of a marriage and the personal legacy of the wars in Iraq and Vietnam. Jewish Alan Golden's past includes an affair with an Arab co-worker, Hala Jaber, that results in the birth of a child, Mariam. His wife Sarah, an actress and acting teacher, forms an intense bond with one of her students, Jeremy Thrasher. He is a talented recently returned Iraq War veteran who triggers visceral memories of a young man from Sarah's own past."
Performances will be Tuesday through Sunday at 7:30 PM with matinees Saturday and Sunday at 2:30 PM.
East Fourth Street Theater is located at 83 East Fourth Street. Tickets are available by calling at (212) 868-4444 or by visiting www.smarttix.com.