Rebecca Faulkenberry (Rock of Ages) will assume the role Nov. 10. T.V Carpio departs the production Nov. 13.
Reeve Carney and Patrick Page will continue on in their roles as Peter Parker/Spider-Man and Norman Osborn/Green Goblin, respectively.
Here is a look at Damiano's final bow:
Jennifer Damiano Takes Final Bow in Spider-Man
Spider-Man features creative consultation by Philip William McKinley, original direction by Tony Award winner Julie Taymor, music and lyrics by 22-time Grammy Award winners Bono and The Edge, and book co-written by Taymor, Glen Berger and Roberto Aguirre-Sacasa.
Inspired by over 40 years of Marvel comic books, Spider-Man, according to press notes, "follows the story of teenager Peter Parker, whose unremarkable life is turned upside-down when he's bitten by a genetically altered spider and wakes up the next morning clinging to his bedroom ceiling. This bullied science-geek suddenly endowed with incredible powers soon learns, however, that with great power comes great responsibility as villains put both his physical strength and strength of character to the test."
For tickets visit Ticketmaster.com.