Michael Sexton directs the work, which has been adapted from Shakespeare's Richard III and Henry VI. Performances will run through Feb. 27.
According to the Red Bull, Margaret, A Tyger's Heart "will explore the journey of one of Shakespeare’s most remarkable characters [Margaret of Anjou], a woman of astonishing variety with an extraordinary arc over four history plays."
Kathleen Chalfant and Michael Stuhlbarg will be special guests at the Feb. 26 performance.
Tickets are available by visiting RedBullTheater or by calling (212) 352-3101. The Theater at St. Clement's is located at 423 West 46th Street in Manhattan.