Tony Award-winning director Jack O'Brien (The Nance) will helm Macbeth, which will officially open Nov. 21 at the Beaumont. Hawke ("Before Midnight") will star in the title role opposite Duff as Lady Macbeth.

The cast will also feature Tony Award winner Easton (The Invention of Love, The Coast of Utopia) as Duncan, Amato (The Coast of Utopia) as Lady Macduff, Tony nominee James (Shrek, Sweet Smell of Success) as Banquo, Orsini (The Nance) as Malcolm, Tony nominee Sunjata (Take Me Out) as Macduff, with Tony nominee Gets (The Story of My Life, A New Brain), Tony winner Glover (Love! Valour! Compassion!) and Byron Jennings as the three Witches.

The cast will also include Shirine Babb (Around the World in 80 Days) as Macbeth Attendant, John Patrick Doherty (The Coward) as Cathness, Austin Durant (War Horse) as Murderer/Siward, Francesca Faridany (Man and Boy) as Hecate, Stephanie Fieger (The Common Pursuit) as Harpier, Ben Horner (War Horse) as Murderer, Ruy Iskandar (Romeo and Juliet) as Donalbain, Aaron Krohn (The Coast of Utopia) as Ross, Jeremiah Maestas (Questa) as Seyton, Christopher McHale (Nikolai and the Others) as Old Man/Doctor, Sam Poon (Billy Elliot) as Macduff's Son, Triney Sandoval (A Free Man of Color) as Menteith, Nathan Stark (As You Like It) as Fleance, Patrick Vaill (When in Disgrace) as Graymalkin, Tyler Lansing Weaks (Sparrow Grass) as Young Siward and Derek Wilson (Agatha Christie) as Lennox.

Macbeth will have set design by Scott Pask, costumes by Catherine Zuber, lighting by Japhy Weideman and original music and sound design by Mark Bennett, projections by Jeff Sugg and fight direction by Steve Rankin.

Performances will be Tuesday-Saturday at 8 PM with matinees Wednesday and Saturday at 2 PM and Sunday at 2 PM. Beginning Nov. 26, all Tuesday evening performances will begin at 7 PM. For tickets, priced $75-$135, visit Telecharge.com or LCT.org.