The trio of comedians will be joined by "Late Night with David Letterman"'s Paul Shaffer on piano for an evening entitled One Night Only at 8 PM. All proceeds from the event benefit Help USA, an organization which primarily focuses on providing assistance to homeless war veterans.

Audiences know Regis Philbin as the host of "Live with Regis and Kelly." His additional screen work includes hosting "Who Wants to Be a Millionaire?" Philbin has lent his voice to such animated features as "Shrek the Third," and "Hercules."

Grodin directed the Broadway productions of Unexpected Guests; Same Time, Next Year; Thieves; and Lovers and Other Strangers. His screen credits include "Saturday Night Live," "The Incredible Shrinking Woman," "Heart and Souls" and "Dave."

Tony Award winner Martin Short has appeared in the Broadway productions of The Goodbye Girl, Little Me (Tony Award), and Martin Short: Fame Becomes Me. His extensive film credits include "The Father of the Bride," "Primetime Glick," "Saturday Night Live" and "Three Amigos."

Tickets to the 90-minute evening of comedy and song – priced $100, $250, and $500 – are available by visiting www.smarttix.com. For further information visit www.helpusa.org. Studio 54 is located at 254 West 54th Street in Manhattan.