Lucy Sexton, who directed Stories Off-Broadway, repeats her duties for the regional premiere, which continues through March 1.

The Boston cast features Josh Lefkowitz, Ain Gordon, Hazelle Goodman and David Cale. Guest performers include Claire Messud, Buddy Cianci and Christopher Lydon.

Conceived by Gray's widow Kathleen Russo, the 90-minute work "brings together excerpts from both renowned and never-before-seen works that span the artist's extraordinary career and life, which ended when he committed suicide in 2004. The five-person cast brings an intense focus to the words, exploring his singular, and often incredibly humorous, quest for self-understanding," according to press notes.

Spalding Gray won an Obie Award for Swimming to Cambodia and filmed the monologue with director Jonathan Demme. Other works include Morning, Noon and Night; Monster in a Box; Gray's Anatomy; and It's a Slippery Slope. He performed on Broadway in Our Town and Gore Vidal's The Best Man. After a series of bouts with depression, Gray took his own life in 2004 by jumping from the Staten Island Ferry into the waters of New York Harbor.

Tickets, priced $20, are available by phoning (617) 478-3103 or by visiting ICABoston. The ICA is located at 100 Northern Avenue on the Boston Waterfront.