The show will be directed by Signature Artistic Director Eric Schaeffer, who staged the piece's world premiere at London's Royal Drury Lane and Prince of Wales theatres.

The Witches of Eastwick, which is based on the novel by John Updike, has book and lyrics by John Dempsey and Dana Rowe, whose musical, The Fix, premiered at the Donmar Warehouse in 1997. The Signature presented The Fix in 1998.

The show has a rocky history. It closed at London's Prince of Wales Oct. 27, 2001. The musical first opened at the Theatre Drury Lane on July 18, 2000, to much ballyhoo and mixed reviews. It was then revamped before opening a second time at the Prince of Wales on July 17, 2001. The transfer was designed to create a more intimate feel to the show, which also received new tunes and some cast changes. A predicted transfer to Broadway didn't materialize. Witches played a three-month run at Melbourne's Princess Theatre in 2002.

In 2001, there was talk of the U.S. national tour for the show, licensed by Mackintosh to Clear Channel, possibly with actor Clarke Peters starring.

Witches will play the Siganture June 5 – July 15, 2007, in The MAX, Signature’s new 299-seat, double-height theatre. Tickets will go on advance sale to subscribers only on June 1. No casting has been announced.