Scott Ellis directs the work, which is scheduled to begin previews Jan. 26, 2010, for a run at the company's midtown home through March 21. Opening night is slated for Feb. 22. Mr. & Mrs. Fitch, penned by Beane (The Little Dog Laughed, Xanadu), centers on two gossip columnists. "When the social circuit no longer provides any scandalous news, they find that great celebrity can appear out of thin air," according to a previous release. The new comedy promises "a scathing look at who is in, who is out and who may not even exist at all."

Lithgow was last seen on Broadway in the revival of All My Sons. His stage work also includes Dirty Rotten Scoundrels, Mrs. Farnsworth, The Retreat From Moscow and his Tony Award-winning turns in The Changing Room and Sweet Smell of Success.

Ehle appeared in The Coast of Utopia, earning her second Tony win for her role in the Tom Stoppard epic. Her first came for her Broadway debut in the 2000 revival of Stoppard's The Real Thing. Other credits include Design for Living and Macbeth.

The design team will feature Allen Moyer (scenic), Jeff Mahshie (costume) and Kenneth Posner (lighting).

Second Stage had previously postponed Mr. & Mrs. Fitch due to director Ellis' scheduling conflict with his duties on the Showtime series "Weeds." The company next presents Anna Deavere Smith's Let Me Down Easy (Sept. 15-Nov. 8).

For more information on Second Stage, 307 West 43rd Street (off Eighth Avenue), call (212) 246-4422 or visit 2ST.com.