Directed by R.J. Cutler, the film will also feature Chloe Moretz ("(500) Days of Summer," "Hugo") and follows a teenager who is in a coma after a car accident.
Enos would play Kat, the girl's mother.
Enos, who was nominated for the Tony Award in 2005 for her performance in Who's Afraid of Virginia Woolf?, has also been seen on Broadway in Absurd Person Singular and The Invention of Love.