As previously reported, the cast will also feature Tony nominee Andrew Rannells, who longs for sunny Orlando but ends up in the less-than-welcoming Uganda in the Tony-winning musical The Book of Mormon.
The 20th Century Fox TV and NBC comedy, co-written by "Glee"'s Ryan Murphy and Allison Adler, will also be directed by Murphy.
The single-camera project is described as "a heartwarming comedy about a blended family of a gay couple and the woman who becomes a surrogate to help them start a family." Barkin would play the mother of the surrogate.
Barkin, who made her Broadway debut last season in Larry Kramer's The Normal Heart, took home the Tony Award for Featured Actress in a Play. She was also awarded a 2011 Theatre World Award and Outer Critics Circle Award for her Normal Heart performance.