Miranda, a Tony winner for his work on Broadway's In the Heights, joins a cast that features Pasquale (Reasons to be Pretty, Off-Broadway's A Man of No Importance) as Dr. Jason Cole/Ian Price, Tony winner Phylicia Rashad (A Raisin in the Sun) as Dr. Vanessa Young, Michael Esper (The Lyons, American Idiot) as Dr. Kenneth Jordan, Alana De La Garza as Dr. Lena Solis, Ruta Gedmintas as Olivia Flynn and Mousa Kraish as Dr. Eli Malak.
The pilot also includes John Carroll Lynch, Toni Trucks, Jason Tam and Samm Levine.
"Do No Harm," currently in production in Philadelphia, is written by David Schulner (An Infinite Ache, Forgiveness) and "centers on Jeffrey Cole (Pasquale), a brilliant neurosurgeon wrestling with his dangerous alter-ego Ian Price (Pasquale) who threatens to wreak havoc on his personal and professional life."
On the series, Miranda will play an attending clinical pharmacologist at a Philadelphia hospital who works to help Dr. Jason Cole/Ian Price.
Peter Traugott, Rachel Kaplan, Mayer and Schulner are executive producers on the Universal TV project.
Pilot director Mayer was a consulting producer on the first season of "Smash." He is a Tony Award winner for his work on Spring Awakening and will stage Verdi's Rigoletto for the Metropolitan Opera, which will begin in January 2013.
Watch a preview of "Do No Harm":