Irma La Douce opened at the Plymouth (now Gerald Schoenfeld) Theatre Sept. 29, 1960. The cast featured Elizabeth Seal as Irma, Keith Michell as Nestor and Clive Revill as Bob-Le-Hotu, the narrator. A young Elliott Gould appeared in the ensemble.
The production received a positive review from the New York Times' Howard Taubman. "If generous, trusting Irma-La-Douce is enough for the milieu," he wrote, "she is all that the stage of the Plymouth Theatre will require for a long while."