The musical version of the hit Broadway comedy Auntie Mame opened May 24, 1966, at the Winter Garden Theatre.
New York Times reviewer Stanley Kauffmann deemed it "a splendidly splashy production" and predicted it would run as long its non-musical counterpart. In fact, Mame went on to play twice as long, enjoying a four-year run of 1,508 performances.
At the 1966 Tonys, the production received eight nominations, including Best Musical. For her starring role, Angela Lansbury took home her first Tony, and Bea Arthur earned an award for her featured performance. Eleven-year-old Frankie Michaels won a Tony for his performance as young Patrick Dennis; he still holds the record as the youngest winner in Tony Award history.