The production finally opened at the Marquis Theatre on Dec. 8, 1991, after 71 previews. The opening-night cast featured several Broadway notables, including Faith Prince, Christine Baranski and Debra Monk. Barry Bostwick and Joanna Gleason starred as husband-and-wife detectives Nick and Nora.
The show had received bad publicity during its troubled preview period and was met with equally harsh reviews after its official opening. Frank Rich of the New York Times called it "an almost instantly forgettable mediocrity." Despite its talented cast and creative team, Nick & Nora could not overcome the negative audience and critical response and closed after just nine performances.