The Monday night series will launch with "The Ladies of Wicked." Scheduled to perform are Libby Servais, Meggie Cansler, Alyssa Fox, Jenn Furman and Alicia Albright.
Tiffany Schleigh and Julie R. Holmes will host the performance, which will be followed by an open mic session.
A portion of the beverage and food proceeds will go to St. Jude's.
There is no cover charge and no minimum. Rachel's is located on West 43rd Street and Ninth Avenue.