Variety reports that instructors and supervisors at the New York City High School of Performing Arts, where the film is set, will include theatre and film veterans Debbie Allen (as the school's principal), Charles S. Dutton (as an acting teacher), Kelsey Grammer (as an orchestra maestro), Megan Mullally (as a voice teacher) and Bebe Neuwirth (as a dance instructor). Allen was also part of the film's original cast.

As previously reported, the film will feature Kristy Flores as a dancer named Rosie, Paul Iacono as filmmaker Neil, Paul McGill a gay dancer named Kevin, Naturi Naughton as a classical pianist named Denise, Kay Panabaker as actress Jenny, Kherington Payne as ballerina Alice, Collins Pennie as an artist named Malik, Walter Perez as a musician named Victor and Anna Maria Perez de Tagle as Joy Moy.

Choreographer Kevin Tancharoen will direct the remake of "Fame," which was penned by Allison Burnett and Aline Brosh McKenna. Lakeshore Entertainment's Gary Lucchesi and Tom Rosenberg are producing with Mark Canton.

The film, according to the Hollywood Reporter, will "track the failures and fortunes of super-ambitious young performers and their teachers as they navigate a school year at the prestigious High School for the Performing Arts in New York."