The latest production of the play represents script revisions since its bow on the West Coast, where JoBeth Williams played the role O'Toole now fills.

Lisa Peterson directs The Quality of Life, playing at Arena Stage's temporary home in Crystal City in Arlington, VA. Opening is Sept. 17. While its Washington, DC, headquarters are being expanded, Arena is playing in borrowed spaces in and around DC.

O'Toole is an Oscar nominee for Best Song for the film "A Mighty Wind." She played Martha Kent on TV's "Smallville." She recently appeared in Magnolia at the Goodman Theatre. Day appeared in Broadway's August: Osage County and Proof and won the Helen Hayes Award for The Rainmaker at Arena Stage. O'Rourke appeared in Broadway's revival of Cat on a Hot Tin Roof with Kathleen Turner. Schnetzer was recently Voltaire in Arena's Legacy of Light and was in the company of Broadway and Arena's The Goat, or Who Is Sylvia?.

The Quality of Life is produced by Arena Stage in association with Jonathan Reinis Productions and Stephen Eich, who plan to take the play to a commercial future.

The creative team includes set designer Neil Patel, costume designer Ilona Somogyi, lighting designer Alexander V. Nichols, sound designer John Gromada and stage manager Susan R. White.

Anderson's plays have been produced Off-Broadway and in theatres around the country, including A.C.T., Actors Theatre of Louisville, the Williamstown Theatre Festival, McCarter Theatre Center, Long Wharf Theatre, the Geffen Playhouse, and Pasadena Playhouse. Her published plays include Looking for Normal, The Baby Dance, Defying Gravity, Smart Choices for the New Century, Lynette at 3am and The Last Time We Saw Her. Other works include The Pink Studio and Hotel Oubliette (Susan Smith Blackburn Prize). Anderson wrote and directed the film "The Prizewinner of Defiance, Ohio." She wrote and directed "Normal" for HBO, which garnered six Emmy Award nominations, three Golden Globe Award nominations, and Directors Guild of America and Writers Guild of America award nominations for outstanding directing and writing. She wrote HBO's "The Positively True Adventures of the Alleged Texas Cheerleader-Murdering Mom," for which she received an Emmy, a Writers Guild Award, and a PEN Center USA Award for Best Teleplay.

Tickets may be purchased online at www.arenastage.org, by phone at (202) 488-3300 or at the Arena Stage Sales Office at 1800 S. Bell Street, Arlington, VA.

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With the opening of the new Mead Center for American Theater in 2010, Arena Stage will be a leading center for the production, presentation, development and study of American theatre. Now in its sixth decade, Arena Stage serves a diverse annual audience of more than 200,000.