McDaniel ("NYPD Blue," A Soldier’s Play) and Milioti (The Retributionists, Stunning) are featured in a cast that includes Bob Braswell, Jimonn Cole, Michael Cullen, Randall Newsome, Roslyn Ruff, John Sierros, Henry Stram and Andrew Weems.

The Heart Is a Lonely Hunter "follows the story of deaf John Singer as he navigates the world without his dearest friend who has been committed to an insane asylum," according to a synopsis. "When Singer moves to a small Southern town, the locals flock to him as a newfound confidant, seeking compassion and understanding from the one person who needs it the most. Singer's isolation in the world is mirrored in a few of the townspeople he meets along the way—a café owner, a rebellious teenager, a black physician, and an idealistic labor organizer—whose dreams have been shattered."

NYTW opened its season with Jessica Blank and Erik Jensen's Aftermath and will continue with Geoffrey Cowan and Leroy Aarons' Top Secret: The Battle for the Pentagon Papers (a co-production with Los Angeles Theatre Works and Affinity Collaborative Theater).

Tickets to of The Heart Is a Lonely Hunter at NYTW, located at 79 East Fourth Street, are available by calling the box office at (212) 460-5475 or via the website. For more information visit nytw.org.