Executive producers Linda Wallem and Liz Brixius created (with Evan Dunsky) the half-hour single-camera dark comedy. A Showtime spokesperson confirmed the start date and returning stars.

Falco stars as the title character Jackie O'Hurley, billed as "a strong-willed and brilliant — but very flawed — emergency room nurse in a complicated New York City hospital. A lapsed Catholic with an occasional weakness for Vicodin and Adderall to get her through the days, Jackie keeps the hospital balanced with her own kind of justice. Every day is a high wire act of juggling patients, doctors, fellow nurses and her own indiscretions."

The first season saw guest turns from such stage names as Blythe Danner, Judith Ivey, Swoosie Kurtz and Elizabeth Marvel among others. Scott Ellis (Curtains) directed a couple episodes.

Falco has appeared on Broadway in Frankie & Johnnie in the Clair de Lune, 'night, Mother and Side Man. Best earned Tony Award nominations for her turns in The Homecoming and A Moon for the Misbegotten. Smith is known for her solo work Twilight: Los Angeles, 1992 and currently appears Off-Broadway in Let Me Down Easy.