Neil Pepe, who directed the recent Broadway revival of Mamet's Speed-The-Plow, stages A Life, which will run through Jan. 2, 2011.

Knight, best known for his role on "Grey's Anatomy," portrays John opposite stage veteran Stewart (Macbeth) as Robert. 

Here is a look at the opening night:

View the Entire Photo Gallery T.R. Knight Photo by Joseph Marzullo/WENN

Here's how the producers bill the play: "A behind-the-scenes peek at the challenge of actors battling to share both a dressing room and the spotlight, A Life in the Theatre follows two actors in a repertory company: Robert, an older, experienced performer and John, a newcomer to the stage. John at first welcomes Robert’s guidance, but soon overshadows his mentor. From rehearsals to reprisals, from ego trips to acting tips, the play gives a glimpse into the complex relationship that develops as the torch is passed from one generation to the next - a passing that wavers from love and mutual respect to impatience and resentment."

For tickets phone (212) 239-6200, or visit Telecharge. The Schoenfeld Theatre is located at 236 West 45th Street.