The cast includes Eric Lenox Abrams (HBO's "Boardwalk Empire") as Avery, Tony Award winner Chuck Cooper (Finian's Rainbow, The Life) as Wining Boy, Brandon J. Dirden (Clybourne Park, Signature's The First Breeze of Summer) as Boy Willie, Jason Dirden (Signature's The First Breeze of Summer) as Lymon, Alexis Holt (South Pacific tour) as Maretha, Mandi Masden (Off-Broadway debut) as Grace, Roslyn Ruff (Signature's Seven Guitars, "The Help") as Berniece and James A. Williams (Signature's My Children! My Africa!) as Doaker.
Wilson was Signature's Playwright-in-Residence in 2006-07. Signature's mission includes returning to the titles of its alumni writers. The Piano Lesson is set in Pittsburgh's Hill District in 1936. In it, according to Signature, "the Charles family battle their surroundings and each other over their shared legacy — an antique piano." The Pulitzer Prize-winning work is the fourth play of Wilson's Century Cycle exploring the black experience in plays set in every decade of the 20th century. It's billed as "a stunning and moving drama of family, history and survival."